The TLR family protein RP105/MD-1 complex

The TLR family protein RP105/MD-1 complex

The radioprotective 105 (RP105)/MD-1 complex is a member of the Toll-like receptor (TLR) family of proteins. We have previously reported that this complex cooperates with the essential lipopolysaccharide (LPS) receptor TLR4/MD-2 complex and plays a crucial role in LPS responses by B cells. Recent evidences suggest that TLRs can also recognize endogenous ligands and promote non-infectious chroni...

Uncovering the TREM-1-TLR connection.

THE INNATE IMMUNE SYSTEM HAS several large genetically encoded receptor families that interact during the detection and elimination of pathogens. The Toll-like receptor (TLR) family recognizes a diverse group of evolutionarily conserved molecules including lipopolysaccharide (LPS), peptidoglycan, and nucleic acids (16). Engagement of these receptors results in proinflammatory signaling. Another...

Expression profiling of TRIM protein family in THP1-derived macrophages following TLR stimulation

Activated macrophages play an important role in many inflammatory diseases including septic shock and atherosclerosis. However, the molecular mechanisms limiting macrophage activation are not completely understood. Members of the tripartite motif (TRIM) family have recently emerged as important players in innate immunity and antivirus. Here, we systematically analyzed mRNA expressions of repres...

On the Dynamics of the Family axd(x − 1) + x

In this paper we consider the dynamics of the real polynomials of degree d + 1 with a fixed point of multiplicity d ≥ 2. Such polynomials are conjugate to fa,d(x) = axd(x−1)+x, a ∈ R{0}, d ∈ N. Our aim is to study the dynamics fa,d in some special cases.

Characterization of APE/Ref-1 Protein Family